Ammonium Hydroxide → HCID 178513742、化合物
反応式
[OH:1][C:2]1[C:3]2[CH:11]=[N:10][CH:9]=[C:8]([C:12]([O:14]C)=O)[C:4]=2[N:5]=[CH:6][N:7]=1.[NH4+:16].[OH-]>CO>[OH:1][C:2]1[C:3]2[CH:11]=[N:10][CH:9]=[C:8]([C:12]([NH2:16])=[O:14])[C:4]=2[N:5]=[CH:6][N:7]=1参加物
4
実験手順
The mixture of methyl 4-hydroxypyrido[4,3-d]pyrimidine-8-carboxylate (47 mg, 0.1 mmol), NH4OH (3 mL) and MeOH (10 mL) was heated to reflux for 20 hours in a sealed tube. The mixture was then concentrated and purified by prep-HPLC to afford the title compound as a white solid (yield 41.1%).
後処理
- temperaturewas heated
- temperatureto reflux for 20 hours in a sealed tube
- concentrationThe mixture was then concentrated
- custompurified by prep-HPLC
出典と根拠
- ORDレコード
- ord-1832a42924764ce6af2fccc537584134
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09440968B2
反応ノート
読み込み中…