Hydrazine → 2-(4-Fluorophenyl)-4-hydroxy-2-methoxybutyric acid hydrazide

HRID 599617ノート

反応式

HRID 599617 の反応式
[NH2:1][NH2:2].[F:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2([O:16][CH3:17])[CH2:14][CH2:13][O:12][C:11]2=[O:15])=[CH:6][CH:5]=1>C(O)C>[F:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]([O:16][CH3:17])([CH2:14][CH2:13][OH:12])[C:11]([NH:1][NH2:2])=[O:15])=[CH:6][CH:5]=1

参加物

4

反応物 2

HCID 9321HydrazineHCID 670671553-(4-Fluorophenyl)-3-methoxydihydrofuran-2-one

生成物 1

HCID 670673452-(4-Fluorophenyl)-4-hydroxy-2-methoxybutyric acid hydrazide収率 96.2%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

A solution of hydrazine (29 mg) in ethanol (0.5 mL) was added to a solution of 3-(4-fluorophenyl)-3-methoxydihydrofuran-2-one (37 mg) in ethanol (1.2 mL), and the reaction solution was stirred at room temperature for 2.5 hours. The reaction solution was concentrated under reduced pressure to obtain 41 mg of the title compound. The property values of the compound are as follows.

後処理

  1. concentrationThe reaction solution was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-a46867e10ee445f8a61e0ee1878f124a
出典データセット
uspto-grants-2011_03
特許番号
US07897632B2

反応ノート

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