Hydrochloric Acid → 4-Chloro-2-(3,4,5-trifluorophenyl)butyric acid hydrazide hydrochloride
反応式
Cl.[Cl:2][CH2:3][CH2:4][CH:5]([C:17]1[CH:22]=[C:21]([F:23])[C:20]([F:24])=[C:19]([F:25])[CH:18]=1)[C:6]([NH:8][NH:9]C(OC(C)(C)C)=O)=[O:7]>C(OCC)(=O)C>[ClH:2].[Cl:2][CH2:3][CH2:4][CH:5]([C:17]1[CH:18]=[C:19]([F:25])[C:20]([F:24])=[C:21]([F:23])[CH:22]=1)[C:6]([NH:8][NH2:9])=[O:7]参加物
実験手順
A solution of 4 N hydrogen chloride in ethyl acetate (20 mL) was added to tert-butyl N′-[4-chloro-2-(3,4,5-trifluorophenyl)butyryl]hydrazinecarboxylate (1.35 g). The reaction solution was stirred at room temperature for one hour and then concentrated under reduced pressure to obtain 4-chloro-2-(3,4,5-trifluorophenyl)butyric acid hydrazide hydrochloride (1.18 g). A solution of 4-chloro-2-(3,4,5-trifluorophenyl)butyric acid hydrazide hydrochloride (552 mg) and triethylamine (0.95 mL) in ethanol (10 mL) was added to a solution of ethyl(E)-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]acrylimidate dihydrochloride (500 mg) and triethylamine (1 mL) in ethanol (10 mL) at room temperature, and the reaction solution was stirred at 80° C. for 21 hours. The reaction solution was left to cool to room temperature and concentrated under reduced pressure. A saturated sodium bicarbonate solution was added to the resulting residue, followed by extraction with chloroform. The resulting extract was dried over magnesium sulfate and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (carrier: Chromatorex NH; elution solvent: heptane-ethyl acetate system) to obtain 131 mg of the title compound as a racemate. The property values of the compound are as follows.
後処理
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-c0a192815f5b4d04984df84eb567a9a7
- 出典データセット
- uspto-grants-2011_03
- 特許番号
- US07897632B2
反応ノート
読み込み中…