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[5-(Trifluoromethyl)pyridin-2-yl]methanamine → 4-(((5-(Trifluoromethyl)pyridin-2-yl)methyl)amino)benzo[d][1,2,3]triazine-8-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | [5-(Trifluoromethyl)pyridin-2-yl]methanamine | HCID 3796375 | — |
| 反応物 | 4-oxo-1H-1,2,3-benzotriazine-8-carboxamide | HCID 178513613 | — |
| 生成物 | 4-(((5-(Trifluoromethyl)pyridin-2-yl)methyl)amino)benzo[d][1,2,3]triazine-8-carboxamide | HCID 76073578 | — |
反応手順
Compound 7 was prepared following general synthetic scheme 7 wherein (5-(trifluoromethyl)-pyridin-2-yl)methanamine was reacted with 4-hydroxybenzo[d][1,2,3]-triazine-8-carboxamide to give the title compound. LC-MS [349 (M+1)], 1H NMR (400 MHz, DMSO-d): δ 9.50 (t, 1H), 9.35 (s, 1H), 8.93 (s, 1H), 8.55 (d, 2H), 8.16 (dd, 1H), 8.05-8.01 (m, 2H), 7.65 (d, 1H), 5.07 (d, 2H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09440968B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-143ee002a12e4c7091af4fc0d04bc553 |
| 出典メモ | uspto-grants-2016_09 |