Morpholine → 1-Benzyl-4-morpholinopiperidine-4-carbonitrile
反応式
[CH2:1]([N:8]1[CH2:13][CH2:12][C:11](O)([C:14]#[N:15])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:17]1[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1>CO>[CH2:1]([N:8]1[CH2:13][CH2:12][C:11]([N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)([C:14]#[N:15])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1参加物
4
実験手順
A solution of 5.25 g (23.8 mmol) 1-benzyl-4-hydroxy-piperidine-4-carbonitrile and 2.2 mL (25.2 mmol) morpholine in 30 mL MeOH was refluxed for 6 h. The mixture was evaporated to dryness i.vac., while the product was obtained in the form of crystals.
後処理
- customThe mixture was evaporated to dryness i.vac
- custom, while the product was obtained in the form of crystals
出典と根拠
- ORDレコード
- ord-ff3233e750fb431f84f96d39c4cb6b6d
- 出典データセット
- uspto-grants-2011_03
- 特許番号
- US07897603B2
反応ノート
読み込み中…