Methyl tetrafluoro-2-(trifluoromethyl)propionate → HCID 86605061、化合物

反応式

[F:1][C:2]([F:13])([F:12])[C:3]([F:11])([C:7]([F:10])([F:9])[F:8])[CH2:4][CH2:5][CH3:6].FC(C(F)(F)F)(C(F)(F)F)C(OC)=[O:17].C([Mg]Br)C>>[F:1][C:2]([F:12])([F:13])[C:3]([F:11])([C:7]([F:8])([F:9])[F:10])[CH:4]([OH:17])[CH2:5][CH3:6]

参加物

反応物 3

HCID 2775518Methyl tetrafluoro-2-(trifluoromethyl)propionate

HCID 19105657HCID 19105657、化合物

HCID 178418443HCID 178418443、化合物

生成物 1

HCID 86605061HCID 86605061、化合物

実験手順

1,1,1,2-Tetrafluoro-2-(trifluoromethyl)-pentane ((CF3)2CFCH2CH2CH3) may be prepared by reacting methyl perfluoroisobutyrate with ethyl magnesium bromide followed by hydrolysis to give 1,1,1,2-tetrafluoro-2-(trifluoromethyl)-3-pentanol. The pentanol is converted to 4,5,5,5-tetrafluoro-4-(trifluoromethyl)-2-pentene by dehydration with phosphorous pentoxide and the double bond saturated by hydrogenation over a palladium on carbon catalyst.