化工社化工社 化学情報印刷レポート · 研究参考用
Benzylamine → 1-Benzyl-3-(4-trifluoromethoxy-phenyl)-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzylamine | HCID 7504 | — |
| 反応物 | 4-Trifluoromethoxy-(2-nitro-vinyl)-benzene | HCID 688233 | — |
| 反応物 | tert-Butyl 4-oxopiperidine-1-carboxylate | HCID 735900 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 1-Benzyl-3-(4-trifluoromethoxy-phenyl)-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine | HCID 11462900 | — |
反応手順
The title compound (0.28 g) was prepared from 0.50 g of 4-oxo-piperidine-1-carboxylic acid tert-butyl ester, 274 μL of benzylamine, and 0.59 g of 1-trifluoromethoxy-4-(2-nitro-vinyl)-benzene using CH2Cl2 as the solvent. MS (ESI): exact mass calculated for C21H19F3N2O, 372.14. found, m/z 373.2 [M+H]+. 1H NMR (400 MHz, CD3OD): 7.44-7.41 (m, 2H), 7.37-7.26 (m, 5H), 7.19-7.17 (m, 3H), 5.15 (s, 2H), 4.37 (s, 2H), 3.51 (t, J=6.3 Hz, 2H), 2.87 (t, J=6.3 Hz, 2H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07897771B2 |
| 出典データセット | uspto-grants-2011_03 |
| ORD ID | ord-f19a1f98b2404abf818e986dcd2ad444 |
| 出典メモ | uspto-grants-2011_03 |