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HRID 600251作成日：2026年10月27日

(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine → [6-(4-Methyl-piperazin-1-yl)-5,6,7,8-tetrahydro-naphthalen-2-yl]-(2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone

https://huagongshe.com/reaction/600251

反応式

関与物質

役割名称HCID仕込み量
反応物(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidineHCID 853151—
反応物6-(4-Methyl-piperazin-1-yl)-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid dihydrochlorideHCID 67272971—
生成物[6-(4-Methyl-piperazin-1-yl)-5,6,7,8-tetrahydro-naphthalen-2-yl]-(2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanoneHCID 67273459—

反応手順

[6-(4-methyl-piperazin-1-yl)-5,6,7,8-tetrahydro-naphthalen-2-yl]-(2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone is prepared from 6-(4-methyl-piperazin-1-yl)-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid dihydrochloride and (R)-(+)-1-(2-pyrrolidinylmethyl)-pyrrolidine in a manner substantially analogous to Procedure C (See herein Example 13). Observed mass 411 (M++1).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07902191B2
出典データセットuspto-grants-2011_03
ORD IDord-31d1d47127ad4b4b8ce2e652ceb3582b
出典メモuspto-grants-2011_03