(S)-Tert-butyl (1-cyano-2-(4-iodophenyl)ethyl)carbamate → (S)-2-amino-3-(4-iodophenyl)propanenitrile

HRID 600295ノート

反応式

HRID 600295 の反応式
[C:1]([C@@H:3]([NH:12]C(=O)OC(C)(C)C)[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([I:11])=[CH:7][CH:6]=1)#[N:2]>C(O)=O>[NH2:12][C@@H:3]([CH2:4][C:5]1[CH:6]=[CH:7][C:8]([I:11])=[CH:9][CH:10]=1)[C:1]#[N:2]

参加物

3

反応物 1

HCID 57999650(S)-Tert-butyl (1-cyano-2-(4-iodophenyl)ethyl)carbamate

生成物 1

HCID 57999652(S)-2-amino-3-(4-iodophenyl)propanenitrile収率 87.9%

試薬・触媒・溶媒 1

HCID 284Formic Acid溶媒

反応条件

温度
50 °C

実験手順

(S)-tert-Butyl 1-cyano-2-(4-iodophenyl)ethylcarbamate (1.4 g) and formic acid (3 mL) were combined and heated at 50° C. for 10 min. Solvent was removed in vacuo and crude material was loaded onto an SCX cartridge. Non-basic impurities were washed off with methanol, then product was eluted with 10% ammonia in methanol. Solvent was removed in vacuo to give (S)-2-amino-3-(4-iodophenyl)propanenitrile (0.900 g).

後処理

  1. customSolvent was removed in vacuo and crude material
  2. washNon-basic impurities were washed off with methanol
  3. washproduct was eluted with 10% ammonia in methanol
  4. customSolvent was removed in vacuo

出典と根拠

ORDレコード
ord-33b7933a967f44bb89bb2a906656a63b
出典データセット
uspto-grants-2011_03
特許番号
US07902181B2

反応ノート

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