Hydrochloric Acid → (1R,2R)-1-Amino-2-phenylcyclopropane-1-carboxylic acid hydrochloride
反応式
[NH2:1][C@:2]1([C:11]([O:13]C)=[O:12])[CH2:4][C@@H:3]1[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[ClH:15]>O>[ClH:15].[NH2:1][C@:2]1([C:11]([OH:13])=[O:12])[CH2:4][C@@H:3]1[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1参加物
4
実験手順
A mixture of (1R,2R)-methyl 1-amino-2-phenylcyclopropanecarboxylate (14 mg), water (4 mL) and hydrochloric acid (37% w/v, 6 mL) was heated under reflux for 6 h. The mixture was evaporated to dryness, triturated with diethyl ether and the solid collected and dried to give the subtitle compound (14 mg) as a colourless solid.
後処理
- temperaturewas heated
- temperatureunder reflux for 6 h
- customThe mixture was evaporated to dryness
- customtriturated with diethyl ether
- customthe solid collected
- customdried
出典と根拠
- ORDレコード
- ord-2697ca3dc3ed4943a0c8c5e28b7f541c
- 出典データセット
- uspto-grants-2011_03
- 特許番号
- US07902181B2
反応ノート
読み込み中…