Water → 5-Iodo-2-(methylthio)benzonitrile
反応式
[CH3:1][S-:2].[Na+].F[C:5]1[CH:12]=[CH:11][C:10]([I:13])=[CH:9][C:6]=1[C:7]#[N:8].O>CS(C)=O>[I:13][C:10]1[CH:11]=[CH:12][C:5]([S:2][CH3:1])=[C:6]([CH:9]=1)[C:7]#[N:8]参加物
5
実験手順
Sodium thiomethoxide (0.142 g) was added to a solution of 2-fluoro-5-iodobenzonitrile (0.5 g) in DMSO (1 mL) and the mixture stirred. An exotherm was noted. After stirring for 90 min, water was added and the solid that precipitated was collected, washed with water and dried at 50° C. under vacuum to leave the subtitle compound as an off-white solid (0.52 g).
後処理
- stirringAfter stirring for 90 min
- customthe solid that precipitated
- customwas collected
- washwashed with water
- customdried at 50° C. under vacuum
出典と根拠
- ORDレコード
- ord-5a4a1bb640f549d697a5ac4e26dfa675
- 出典データセット
- uspto-grants-2011_03
- 特許番号
- US07902181B2
反応ノート
読み込み中…