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3-(2-Cyanoethylaminocarbonyl)benzeneboronic acid → (S)-N-((S)-1-Cyano-2-(3'-(2-cyanoethylcarbamoyl)biphenyl-4-yl)ethyl)piperidine-2-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-(2-Cyanoethylaminocarbonyl)benzeneboronic acid | HCID 3690598 | — |
| 反応物 | (S)-tert-Butyl 2-((S)-1-cyano-2-(4-iodophenyl)ethylcarbamoyl)piperidine-1-carboxylate | HCID 57999629 | — |
| 生成物 | (S)-N-((S)-1-Cyano-2-(3'-(2-cyanoethylcarbamoyl)biphenyl-4-yl)ethyl)piperidine-2-carboxamide | HCID 42641214 | — |
反応手順
Prepared by a process analogous to that described in Method 2 Example 2 using (S)-tert-butyl 2-((S)-1-cyano-2-(4-iodophenyl)ethylcarbamoyl)piperidine-1-carboxylate and 3-(2-cyanoethylcarbamoyl)phenylboronic acid. NMR appeared to show the product was a free base.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07902181B2 |
| 出典データセット | uspto-grants-2011_03 |
| ORD ID | ord-d9a1cef1b27f4107977bac98126baed7 |
| 出典メモ | uspto-grants-2011_03 |