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Water → 4-Tert-butyl-2-nitrobenzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Acetonitrile | HCID 6342 | — |
| 反応物 | Metaperiodic acid | HCID 65185 | — |
| 反応物 | 4-Tert-butyl-1-ethynyl-2-nitrobenzene | HCID 58016208 | — |
| 触媒 | Ruthenium trichloride hydrate | HCID 6093376 | — |
| 溶媒 | Carban tetrachloride | HCID 18353858 | — |
| 生成物 | 4-Tert-butyl-2-nitrobenzoic acid | HCID 257326 | — |
反応手順
4-tert-Butyl-1-ethynyl-2-nitro-benzene (1.662 g, 8.176 mmol) was dissolved in 20 mL carban tetrachloride, 20 mL acetonitrile, and 40 mL water. Periodic acid (9.322 g, 40.89 mmol) was added followed by ruthenium(III)chloride hydrate (85 mg, 0.41 mmol). After stirring of 90 minutes, the resulting mixture was diluted with water and extracted with three portions of dichloromethane. The combined dichloromethane layers wee dried over anhydrous MgSO4, and concentrated in vacuo to yield 4-tert-Butyl-2-nitro-benzoic acid (1.924 g, 86.19 mmol).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07902194B2 |
| 出典データセット | uspto-grants-2011_03 |
| ORD ID | ord-0a4e468f167f4dea97d49e271611b2f9 |
| 出典メモ | uspto-grants-2011_03 |