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Acetic Acid → 6-(tert-butyl)phthalazin-1(2H)-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Hydrazine hydrate (1:1) | HCID 24654 | — |
| 反応物 | 5-tert-Butyl-3-ethoxy-3H-isobenzofuran-1-one | HCID 58016209 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 6-(tert-butyl)phthalazin-1(2H)-one | HCID 57633933 | 92.3% |
反応手順
2.9 g (12 mmol) of 5-tert-butyl-3-ethoxy-3H-isobenzofuran-1-one was weighed into a 50 mL round bottom flask fitted with a stir bar and cap. Added 10 mL (130 mmol) of hydrazine monohydrate. Added 15 mL of glacial acetic acid. Stirred at 100° overnight. Poured the reaction mixture into 200 mL of stirred water. Collected the solids by filtration and washed with water. Dried under high vacuum to obtain 2.24 g of the title compound as an off-white solid. MS (ESI) 203 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07902194B2 |
| 出典データセット | uspto-grants-2011_03 |
| ORD ID | ord-cf94e078f67449099c865a142bbe3ffa |
| 出典メモ | uspto-grants-2011_03 |