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Pyrimidine-4-carbohydrazide → N-pentyl-5-(3-pyrimidin-4-yl-1H-1,2,4-triazol-5-yl)-1H-imidazol-4-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyrimidine-4-carbohydrazide | HCID 468664 | — |
| 反応物 | methyl 4-(pentylamino)-1H-imidazole-5-carbimidothioate | HCID 135984704 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | N-pentyl-5-(3-pyrimidin-4-yl-1H-1,2,4-triazol-5-yl)-1H-imidazol-4-amine | HCID 135984710 | — |
反応手順
The mixture of methyl 4-(pentylamino)-1H-imidazole-5-carbimidothioate (1.5 g, 6.6 mmol) and pyrimidine-4-carbohydrazide (1.2 g, 8.7 mmol) in ethanol (10 mL) was refluxed overnight. The reaction mixture was concentrated under reduced pressure to yield the desired product as light green viscous oil. LCMS calculated for C14H19N8 (M+H): 299.2. found: 299.1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07902205B2 |
| 出典データセット | uspto-grants-2011_03 |
| ORD ID | ord-0301d54d96ba4cd38f06a91539f71db0 |
| 出典メモ | uspto-grants-2011_03 |