Hydrochloric Acid → (6-Methylimidazo[1,2-a]pyridin-2-yl)phenylmethanone hydrochloride

HRID 600615ノート

反応式

HRID 600615 の反応式
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[O:12])[N:10]=2)[CH:7]=1.[ClH:19].C(OCC)C>C(O)C.O1CCOCC1>[ClH:19].[CH3:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[O:12])[N:10]=2)[CH:7]=1

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 24768843(6-Methylimidazo[1,2-a]pyridin-2-yl)phenylmethanone

生成物 1

HCID 24768842(6-Methylimidazo[1,2-a]pyridin-2-yl)phenylmethanone hydrochloride

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 312751,4-Dioxane溶媒

実験手順

120 mg of (6-methylimidazo[1,2-a]pyridin-2-yl)phenylmethanone are taken up in 2 mL of ethanol and the solution is treated with 1.5 mL of a 4N solution of hydrogen chloride in dioxane and then with 2 mL of diethyl ether. The crystals obtained are filtered off and washed with diethyl ether, and then dried. 77 mg of (6-methylimidazo[1,2-a]pyridin-2-yl)phenylmethanone hydrochloride (1:1) are obtained in the form of a beige-colored solid.

後処理

  1. customThe crystals obtained
  2. filtrationare filtered off
  3. washwashed with diethyl ether
  4. customdried

出典と根拠

ORDレコード
ord-445964f76f124d37b0ef99fba4cea7ba
出典データセット
uspto-grants-2011_03
特許番号
US07902219B2

反応ノート

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