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5-Quinolinamine, 2-methyl- → 3-(1-Ethyl-1,2,3,4-tetrahydro-1-naphthalenyl)-1,1,1-trifluoro-2-[[(2-methyl-5-quinolinyl) amino]methyl]-2-propanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Quinolinamine, 2-methyl- | HCID 148683 | — |
| 反応物 | 2-[(1-Ethyl-1,2,3,4-tetrahydro-1-naphthalenyl)methyl]-2-(trifluoromethyl)oxirane | HCID 11630585 | — |
| 生成物 | 3-(1-Ethyl-1,2,3,4-tetrahydro-1-naphthalenyl)-1,1,1-trifluoro-2-[[(2-methyl-5-quinolinyl) amino]methyl]-2-propanol | HCID 11568433 | — |
反応手順
Similar reaction of 2-[(1-ethyl-1,2,3,4-tetrahydro-1-naphthalenyl)methyl]-2-(trifluoromethyl)oxirane (D2, racemic diastereomer 2) (Intermediate 15) with 2-methyl-5-quinolinamine afforded Example 5-D2 (racemic diastereomer 2).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07902224B2 |
| 出典データセット | uspto-grants-2011_03 |
| ORD ID | ord-eb3788e442fe4939a2b42801005995fa |
| 出典メモ | uspto-grants-2011_03 |