HCID 53416493、化合物 → HCID 67228763、化合物

HRID 600812

反応式

HRID 600812 の反応式
[C:1]([O:5][C:6](=[O:21])[NH:7][CH:8]1[CH2:17][CH2:16][C:15]2[C:10](=[C:11]([N:18]=[C:19]=S)[CH:12]=[CH:13][CH:14]=2)[CH2:9]1)([CH3:4])([CH3:3])[CH3:2].C(OC1CC2C(CC=1)=CC=CC=2N=C=S)C.[N:38]([CH2:41][C:42]([C:44]1[CH:49]=[CH:48][C:47]([C:50]([F:53])([F:52])[F:51])=[CH:46][C:45]=1[F:54])=[O:43])=[N+]=[N-].N(CC(C1C=CC(C(F)(F)F)=CC=1)=O)=[N+]=[N-]>>[C:1]([O:5][C:6](=[O:21])[NH:7][CH:8]1[CH2:17][CH2:16][C:15]2[C:10](=[C:11]([NH:18][C:19]3[O:43][C:42]([C:44]4[CH:49]=[CH:48][C:47]([C:50]([F:51])([F:52])[F:53])=[CH:46][C:45]=4[F:54])=[CH:41][N:38]=3)[CH:12]=[CH:13][CH:14]=2)[CH2:9]1)([CH3:4])([CH3:3])[CH3:2]

参加物

5

反応物 4

HCID 53416493HCID 53416493、化合物HCID 866096122-Ethoxy-8-isothiocyanato-1,4-dihydronaphthaleneHCID 86609614HCID 86609614、化合物HCID 86609615HCID 86609615、化合物

生成物 1

HCID 67228763HCID 67228763、化合物収率 16%

実験手順

The title compound was prepared using the procedure as described in Example 1H, substituting the product of Example 20F (415 mg, 1.36 mmol) for the product of Example 1F and the product of Example 22A (404 mg, 1.63 mmol) for the product of Example 1G. The crude product was purified by flash chromatography eluting with 20% to 60% EtOAc/hexanes which gave 107 mg (16%) of the title compound as a yellow solid.

後処理

  1. customThe title compound was prepared
  2. customThe crude product was purified by flash chromatography
  3. washeluting with 20% to 60% EtOAc/hexanes which

出典と根拠

ORDレコード
ord-8a3701485d6247e7843411af5deb8e45
出典データセット
uspto-grants-2011_03
特許番号
US07902236B2

関連ノート

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