3-(R)-[1-[N-(tert-butoxycarbonyl)-N-(ethyl)Amino]Cyclopropyl]-1-[1-(S)-phenylethyl]Pyrrolidine → 3-(R)-[1-[N-(tert-butoxycarbonyl)-N-(ethyl)amino]cyclopropyl]pyrrolidine

HRID 600903ノート

反応式

HRID 600903 の反応式
[C:1]([O:5][C:6]([N:8]([C:11]1([C@@H:14]2[CH2:18][CH2:17][N:16]([C@H](C3C=CC=CC=3)C)[CH2:15]2)[CH2:13][CH2:12]1)[CH2:9][CH3:10])=[O:7])([CH3:4])([CH3:3])[CH3:2]>C(O)C.[C].[Pd]>[C:1]([O:5][C:6]([N:8]([C:11]1([C@@H:14]2[CH2:18][CH2:17][NH:16][CH2:15]2)[CH2:13][CH2:12]1)[CH2:9][CH3:10])=[O:7])([CH3:2])([CH3:3])[CH3:4]

参加物

4

反応物 1

HCID 672719343-(R)-[1-[N-(tert-butoxycarbonyl)-N-(ethyl)Amino]Cyclopropyl]-1-[1-(S)-phenylethyl]Pyrrolidine

生成物 1

HCID 672707243-(R)-[1-[N-(tert-butoxycarbonyl)-N-(ethyl)amino]cyclopropyl]pyrrolidine

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 702Ethanol溶媒

反応条件

温度
40 °C

実験手順

3-(R)-[1-[N-(tert-butoxycarbonyl)-N-(ethyl)amino]cyclopropyl]-1-[1-(S)-phenylethyl]pyrrolidine (3.01 g, 8.40 mmol) was dissolved in ethanol (120 ml), and after adding a 10% palladium carbon catalyst (water content: 50%; 3.0 g), it was stirred at 40° C. for 5 hours under a hydrogen atmosphere at atmospheric pressure. After performing filtration through cellite (ethanol washing), the filtrate was concentrated under a reduced pressure. As a result, 2.16 g (quantitative) of the title compound was obtained in the form of a colorless syrup.

後処理

  1. filtrationfiltration through cellite (ethanol washing)
  2. concentrationthe filtrate was concentrated under a reduced pressure

出典と根拠

ORDレコード
ord-fe82bc07047d40818c3561c6ab4b6421
出典データセット
uspto-grants-2011_03
特許番号
US07902226B2

反応ノート

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