Hydrochloric Acid → 2-(4-Fluorophenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine-7-carboxylic acid

HRID 60142ノート

反応式

HRID 60142 の反応式
Cl.[F:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:20]=[C:12]3[CH2:13][CH:14]([C:17]([O-:19])=[O:18])[CH2:15][CH2:16][N:11]3[N:10]=2)=[CH:5][CH:4]=1.[Na+]>>[F:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:20]=[C:12]3[CH2:13][CH:14]([C:17]([OH:19])=[O:18])[CH2:15][CH2:16][N:11]3[N:10]=2)=[CH:5][CH:4]=1

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 117776381Sodium 2-(4-fluorophenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine-7-carboxylate

生成物 1

HCID 839653482-(4-Fluorophenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine-7-carboxylic acid収率 40.1%

実験手順

Concentrated hydrochloric acid (0.16 ml) was added to an aqueous solution (2 ml) of the sodium 2-(4-fluorophenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine-7-carboxylate (530 mg) obtained in (Example 5.2) <Step 2>, and the obtained mixture was then stirred for 15 minutes. Thereafter, the precipitated solid was collected by filtration, so as to obtain the title compound (196 mg) in the form of a whitish brown solid.

後処理

  1. customobtained in (Example 5.2) <Step 2>
  2. filtrationThereafter, the precipitated solid was collected by filtration

出典と根拠

ORDレコード
ord-7b7af2c4c64f4917a04b13dfb4b6fb49
出典データセット
uspto-grants-2016_09
特許番号
US09440970B2

反応ノート

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