化工社化工社 化学情報印刷レポート · 研究参考用
1-(2-Methoxy-4-nitro-phenyl)-4-triisopropylsilanyloxy-piperidine → 3-Methoxy-4-(4-triisopropylsilanyloxy-piperidin-1-yl)-phenylamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(2-Methoxy-4-nitro-phenyl)-4-triisopropylsilanyloxy-piperidine | HCID 57501700 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 3-Methoxy-4-(4-triisopropylsilanyloxy-piperidin-1-yl)-phenylamine | HCID 57501706 | 100.3% |
反応手順
Dissolve 1-(2-Methoxy-4-nitro-phenyl)-4-triisopropylsilanyloxy-piperidine (1.53 g, 3.74 mmol) in THF (30 mL) and add 5% Pd/C then stir the slurry at room temperature under a hydrogen atmosphere for 3 h. Filter the black mixture through a pad of Celite® and concentrate the filtrate in vacuo to give 3-methoxy-4-(4-triisopropylsilanyloxy-piperidin-1-yl)-phenylamine (1.42 g, 100%) that was used immediately.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07902356B2 |
| 出典データセット | uspto-grants-2011_03 |
| ORD ID | ord-81acc41c2427466fa3067f1be0088242 |
| 出典メモ | uspto-grants-2011_03 |