Hydrochloric Acid → 2-[2-(2-Fluoro-ethyl)-2H-tetrazol-5-yl]-ethylamine
反応式
C(OC(=O)[NH:7][CH2:8][CH2:9][C:10]1[N:11]=[N:12][N:13]([CH2:15][CH2:16][F:17])[N:14]=1)(C)(C)C.Cl>C(Cl)Cl>[F:17][CH2:16][CH2:15][N:13]1[N:12]=[N:11][C:10]([CH2:9][CH2:8][NH2:7])=[N:14]1参加物
4
実験手順
A solution of {2-[2-(2-Fluoro-ethyl)-2H-tetrazol-5-yl]-ethyl}-carbamic acid tert-butyl ester (step 1) (0.025 g, 0.0964 mmol) in DCM (3 ml) is treated with hydrochloric acid (1 ml, 4M in dioxane) and allowed to stir at room temperature for 1 hour. The reaction mixture is concentrated in vacuo to yield the titled compound as a white solid.
後処理
- concentrationThe reaction mixture is concentrated in vacuo
出典と根拠
- ORDレコード
- ord-9cbe70fe0deb4dcb8ea02952d9df9e17
- 出典データセット
- uspto-grants-2011_03
- 特許番号
- US07902375B2
反応ノート
読み込み中…