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Tetrahydrofuran → N-(2-methylcyclopentyl)-3,4-difluorobenzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 3,4-Difluorobenzoyl chloride | HCID 2724519 | — |
| 反応物 | 2-Methylcyclopentan-1-amine hydrochloride | HCID 19101439 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | N-(2-methylcyclopentyl)-3,4-difluorobenzamide | HCID 57445707 | 84.3% |
反応手順
To a mixture of 10 ml of THF and 0.60 g of 3,4-difluorobenzoyl chloride were added 0.37 g of 2-methylcyclopentylamine hydrochloride and 1.0 g of triethylamine, and the mixture obtained was stirred at room temperature for 3 hours. Then, ethyl acetate was added to the reaction mixture and filtered through Celite. The filtrate was concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to obtain 0.55 g of N-(2-methylcyclopentyl)-3,4-difluorobenzamide.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07902400B2 |
| 出典データセット | uspto-grants-2011_03 |
| ORD ID | ord-8ab286347c77495d9716b68571a0fd09 |
| 出典メモ | uspto-grants-2011_03 |