化工社化工社 化学情報印刷レポート · 研究参考用
Thionyl Chloride → 3-Methoxy-4-(2-propynyloxy)benzoyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | 3-Methoxy-4-(prop-2-ynyloxy)benzoic acid | HCID 13121480 | — |
| 触媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 3-Methoxy-4-(2-propynyloxy)benzoyl chloride | HCID 57445671 | 84.1% |
反応手順
To 100 ml of toluene were added 12.0 g of 4-(2-propynyloxy)-3-methoxybenzoic acid, 9.0 g of thionyl chloride and 50 mg of DMF, and the mixture obtained was heated under reflux for 3 hours. Then, the reaction mixture was concentrated. The solid obtained was washed with hexane to obtain 11.0 g of 4-(2-propynyloxy)-3-methoxybenzoyl chloride represented by the formula.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07902400B2 |
| 出典データセット | uspto-grants-2011_03 |
| ORD ID | ord-c4844b0198954552a6ae17f7c6d001e8 |
| 出典メモ | uspto-grants-2011_03 |