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Toluene → 6-(2-Fluorophenyl)nicotinic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Toluene | HCID 1140 | — |
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | Tert-butyl 6-(2-fluorophenyl)nicotinate | HCID 67267995 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 6-(2-Fluorophenyl)nicotinic acid | HCID 24729971 | 98.7% |
反応手順
To tert-butyl 6-(2-fluorophenyl)nicotinate (479 mg, 1.75 mmol) in DCM (12 mL) at 0° C. was added TFA (2.5 mL). After stirring at rt overnight, toluene was added (10 mL) and the solvent removed to give a white solid (375 mg, 98%), 6-(2-fluorophenyl)nicotinic acid. LC/MS (M+H)=218.0 observed, 218.06 expected.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07902373B2 |
| 出典データセット | uspto-grants-2011_03 |
| ORD ID | ord-e8914897738a41368082a8bb2d310a98 |
| 出典メモ | uspto-grants-2011_03 |