4-Benzylmorpholine-2-carboxylic acid hydrochloride → Methyl 4-benzylmorpholine-2-carboxylate

HRID 602131

反応式

HRID 602131 の反応式
Cl.[CH2:2]([N:9]1[CH2:14][CH2:13][O:12][CH:11]([C:15]([OH:17])=[O:16])[CH2:10]1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.Cl.[CH3:19]O>>[CH2:2]([N:9]1[CH2:14][CH2:13][O:12][CH:11]([C:15]([O:17][CH3:19])=[O:16])[CH2:10]1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

参加物

3

反応物 2

HCID 27763524-Benzylmorpholine-2-carboxylic acid hydrochlorideHCID 21893726Hydrochloride methanol

生成物 1

HCID 50989152Methyl 4-benzylmorpholine-2-carboxylate収率 80%

実験手順

4-Benzylmorpholine-2-carboxylic acid hydrochloride (1.00 g, 3.88 mmol) in a 10 (w/w) % hydrochloric acid/methanol solution (20 mL) was stirred at room temperature for 2 hours. The solvent was evaporated and a saturated aqueous sodium bicarbonate solution was added to the residue to make the mixture basic. The mixture was then extracted with ethyl acetate and the extract washed with brine and was dried over magnesium sulfate. Evaporation of the solvent gave 730 mg (80%) of the desired compound as a colorless oil.

後処理

  1. customThe solvent was evaporated
  2. additiona saturated aqueous sodium bicarbonate solution was added to the residue
  3. extractionThe mixture was then extracted with ethyl acetate
  4. washthe extract washed with brine
  5. dry with materialwas dried over magnesium sulfate
  6. customEvaporation of the solvent

出典と根拠

ORDレコード
ord-71ee93e16bae4d76a593d200f4928bb8
出典データセット
uspto-grants-2011_03
特許番号
US07902367B2

関連ノート

読み込み中…