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1-Boc-3-hydroxypiperidine → 1-(tert-Butoxycarbonyl)-3-[[2-(4-chlorophenyl)-4-methylthiazol-5-yl]methoxy]piperidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Boc-3-hydroxypiperidine | HCID 545699 | — |
| 反応物 | 5-(Chloromethyl)-2-(4-chlorophenyl)-4-methyl-1,3-thiazole | HCID 2763694 | — |
| 生成物 | 1-(tert-Butoxycarbonyl)-3-[[2-(4-chlorophenyl)-4-methylthiazol-5-yl]methoxy]piperidine | HCID 57572140 | 44.2% |
反応手順
Using 1-(tert-butoxycarbonyl)-3-hydroxypiperidine (201 mg, 1.00 mmol) and 5-chloromethyl-2-(4-chlorophenyl)-4-methylthiazole (258 mg, 1.00 mmol), the same procedure was followed as in Step 5a of Example 5 to give 187 mg (44%) of the desired compound as a colorless oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07902367B2 |
| 出典データセット | uspto-grants-2011_03 |
| ORD ID | ord-6fcabbb6b52b4193a2399ef056a7b722 |
| 出典メモ | uspto-grants-2011_03 |