Water → 3-[4-(4-Fluorophenoxy)benzyloxy]piperidine

HRID 602186ノート

反応式

HRID 602186 の反応式
[OH-].[K+].FC(F)(F)C([N:7]1[CH2:12][CH2:11][CH2:10][CH:9]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][C:18]([O:21][C:22]3[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=3)=[CH:17][CH:16]=2)[CH2:8]1)=O.O>CO>[F:28][C:25]1[CH:26]=[CH:27][C:22]([O:21][C:18]2[CH:17]=[CH:16][C:15]([CH2:14][O:13][CH:9]3[CH2:10][CH2:11][CH2:12][NH:7][CH2:8]3)=[CH:20][CH:19]=2)=[CH:23][CH:24]=1

参加物

5

反応物 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 589925921-Trifluoroacetyl-3-[4-(4-fluorophenoxy)benzyloxy]piperidine

生成物 1

HCID 589926953-[4-(4-Fluorophenoxy)benzyloxy]piperidine収率 95.6%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A 1 mol/L aqueous potassium hydroxide solution (2 mL) was added to 1-trifluoroacetyl-3-[4-(4-fluorophenoxy)benzyloxy]piperidine (434 mg, 1.09 mmol) in methanol (4 mL). The mixture was refluxed for 2 hours and was allowed to cool. Water was then added and the mixture was extracted with ethyl acetate. The organic layer was washed with brine and the washed product was dried over magnesium sulfate. The solvent was evaporated to give 314 mg (95%) of the desired compound as a colorless oil.

後処理

  1. temperatureThe mixture was refluxed for 2 hours
  2. temperatureto cool
  3. extractionthe mixture was extracted with ethyl acetate
  4. washThe organic layer was washed with brine
  5. dry with materialthe washed product was dried over magnesium sulfate
  6. customThe solvent was evaporated

出典と根拠

ORDレコード
ord-595462e0dfde48798d401963a45daa78
出典データセット
uspto-grants-2011_03
特許番号
US07902367B2

反応ノート

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