1-Benzyloxycarbonyl-3-[2-[2-(4-chlorophenyl)-4-methylthiazol-5-yl]ethenyl]piperidine → 3-[2-[2-(4-Chlorophenyl)-4-methylthiazol-5-yl]ethenyl]piperidine

HRID 602196ノート

反応式

HRID 602196 の反応式
C(OC([N:11]1[CH2:16][CH2:15][CH2:14][CH:13]([CH:17]=[CH:18][C:19]2[S:23][C:22]([C:24]3[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][CH:25]=3)=[N:21][C:20]=2[CH3:31])[CH2:12]1)=O)C1C=CC=CC=1>Cl>[Cl:30][C:27]1[CH:28]=[CH:29][C:24]([C:22]2[S:23][C:19]([CH:18]=[CH:17][CH:13]3[CH2:14][CH2:15][CH2:16][NH:11][CH2:12]3)=[C:20]([CH3:31])[N:21]=2)=[CH:25][CH:26]=1

参加物

3

反応物 1

HCID 672674511-Benzyloxycarbonyl-3-[2-[2-(4-chlorophenyl)-4-methylthiazol-5-yl]ethenyl]piperidine

生成物 1

HCID 672670783-[2-[2-(4-Chlorophenyl)-4-methylthiazol-5-yl]ethenyl]piperidine収率 92%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

1-Benzyloxycarbonyl-3-[2-[2-(4-chlorophenyl)-4-methylthiazol-5-yl]ethenyl]piperidine (1.16 g, 2.56 mmol) in 6 mol/L hydrochloric acid (25 mL) was stirred for 1 hour while being refluxed. Subsequently, the reaction mixture washed with ethyl acetate. A 10 mol/L aqueous sodium hydroxide solution was then added to make the mixture basic and the mixture was extracted with ethyl acetate. The extract washed with brine, followed by drying over magnesium sulfate and evaporation of the solvent. The residue was air-dried to give 749 mg (92%) of the desired compound as a yellow powder.

後処理

  1. temperaturewhile being refluxed
  2. washSubsequently, the reaction mixture washed with ethyl acetate
  3. additionA 10 mol/L aqueous sodium hydroxide solution was then added
  4. extractionthe mixture was extracted with ethyl acetate
  5. washThe extract washed with brine
  6. dry with materialby drying over magnesium sulfate and evaporation of the solvent
  7. customThe residue was air-dried

出典と根拠

ORDレコード
ord-27b844eb270344d99ae76514f6bcf323
出典データセット
uspto-grants-2011_03
特許番号
US07902367B2

反応ノート

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