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5-(Chloromethyl)-2-(4-chlorophenyl)-4-methyl-1,3-thiazole → 4-(tert-Butoxycarbonyl)-2-[[2-(4-chlorophenyl)-4-methylthiazol-5-yl]methoxymethyl]morpholine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-(Chloromethyl)-2-(4-chlorophenyl)-4-methyl-1,3-thiazole | HCID 2763694 | — |
| 反応物 | tert-Butyl 2-(hydroxymethyl)morpholine-4-carboxylate | HCID 5201202 | — |
| 生成物 | 4-(tert-Butoxycarbonyl)-2-[[2-(4-chlorophenyl)-4-methylthiazol-5-yl]methoxymethyl]morpholine | HCID 58992586 | 69% |
反応手順
Using 4-(tert-butoxycarbonyl)morpholin-2-ylmethanol (217 mg, 1.00 mmol) and 5-chloromethyl-2-(4-chlorophenyl)-4-methylthiazole (258 mg, 1.00 mmol), the same procedure was followed as in Step 5a of Example 5 to give 303 mg (69%) of the desired compound as a yellow oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07902367B2 |
| 出典データセット | uspto-grants-2011_03 |
| ORD ID | ord-a8c8ab09ba804ad1883e637058be9dde |
| 出典メモ | uspto-grants-2011_03 |