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4-Chloroaniline → tert-butyl (R)-2-(4-chlorophenylcarbamoyl)pyrrolidine-1-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Chloroaniline | HCID 7812 | — |
| 反応物 | 2-Ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinoline | HCID 27833 | — |
| 反応物 | (2R)-1-[(tert-butoxy)carbonyl]pyrrolidine-2-carboxylic acid | HCID 688022 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | tert-butyl (R)-2-(4-chlorophenylcarbamoyl)pyrrolidine-1-carboxylate | HCID 9138711 | — |
反応手順
4.82 g (19.5 mmol) of ethyl 2-ethoxy-1,2-dihydroquinoline-1-carboxylate (EEDQ) are added to a suspension of 2.80 g (13.0 mmol) of N-Boc-D-proline and 1.66 g (13.0 mmol) of 4-chloroaniline in 50 ml of toluene, and the mixture is stirred at room temperature for 3 hours. The reaction mixture is filtered, and petroleum ether is added to the filtrate. The precipitate formed is filtered off and dried, giving tert-butyl (R)-2-(4-chlorophenylcarbamoyl)pyrrolidine-1-carboxylate as colourless crystals; ESI 325.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07906516B2 |
| 出典データセット | uspto-grants-2011_03 |
| ORD ID | ord-3d4be8b56c6e4a41abd341a00e524224 |
| 出典メモ | uspto-grants-2011_03 |