Morpholine → Morpholine-4-carboxamide

HRID 602427

反応式

HRID 602427 の反応式
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.C[Si]([N:11]=[C:12]=[O:13])(C)C>C(O)(C)C>[N:1]1([C:12]([NH2:11])=[O:13])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

参加物

4

反応物 2

HCID 8083MorpholineHCID 70696Trimethylsilyl isocyanate

生成物 1

HCID 75088Morpholine-4-carboxamide収率 102.4%

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

To a stirred solution of morpholine (1.3 mL, 15 mmol) in isopropanol (30 mL) at rt was added trimethylsilylisocyanate (2.8 mL, 21 mmol) and the resulting solution stirred overnight before the volatiles were removed in vacuo to give morpholine-4-carboxylic acid amide (2.0 g, quant.) as a solid; 1H-NMR (300 MHz, d6-DMSO) 6.00 (2H, s), 3.51-3.54 (4H, s), 3.23-3.26 (4H, s).

後処理

  1. customwere removed in vacuo

出典と根拠

ORDレコード
ord-72b796d8e7204dd599c7a71d3fddf1fd
出典データセット
uspto-grants-2011_03
特許番号
US07906533B2

関連ノート

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