Ethyl 2-(5-((tert-butoxycarbonyl)amino)pyridin-2-yl)acetate → Ethyl {cis-5-[(tert-butoxycarbonyl)amino]piperidin-2-yl}acetate

HRID 602445ノート

反応式

HRID 602445 の反応式
[C:1]([O:5][C:6]([NH:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])=[N:13][CH:14]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>C(O)C.C(O)(=O)C.[Pt]=O>[C:1]([O:5][C:6]([NH:8][C@H:9]1[CH2:14][NH:13][C@@H:12]([CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH2:11][CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

参加物

5

反応物 1

HCID 59224181Ethyl 2-(5-((tert-butoxycarbonyl)amino)pyridin-2-yl)acetate

生成物 1

HCID 86624143Ethyl {cis-5-[(tert-butoxycarbonyl)amino]piperidin-2-yl}acetate収率 65%

試薬・触媒・溶媒 3

HCID 82844Platinum oxide (PtO)触媒HCID 176Acetic Acid溶媒HCID 702Ethanol溶媒

実験手順

The mixture of ethyl {5-[(tert-butoxycarbonyl)amino]pyridin-2-yl}acetate (3.72 g, 15.6 mmol, step 4 of Example 1) and platinum oxide (300 mg) in ethanol (6 mL) and acetic acid (6 mL) was stirred under hydrogen (4 atom) at room temperature for 8 h. The mixture was filtered through a pad of Celite washing with ethanol and the filtrate was concentrated. The resulting residue was diluted with 2N aqueous sodium hydroxide solution (100 mL), and extracted with dichloromethane (100 mL×3). The combined organic layer was dried over magnesium sulfate, and concentrated under reduced pressure. The resulting residue was chromatographed on a column of silica gel eluting with dichloromethane/methanol (20:1) to give 2.48 g (65%) of the title compound as a colorless oil. (trans isomer 559 mg, 15% yield)

後処理

  1. filtrationThe mixture was filtered through a pad of Celite
  2. washwashing with ethanol
  3. concentrationthe filtrate was concentrated
  4. additionThe resulting residue was diluted with 2N aqueous sodium hydroxide solution (100 mL)
  5. extractionextracted with dichloromethane (100 mL×3)
  6. dry with materialThe combined organic layer was dried over magnesium sulfate
  7. concentrationconcentrated under reduced pressure
  8. customThe resulting residue was chromatographed on a column of silica gel eluting with dichloromethane/methanol (20:1)

出典と根拠

ORDレコード
ord-2a30f998b1d34ba495186161ff7fc25b
出典データセット
uspto-grants-2011_03
特許番号
US07906532B2

反応ノート

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