Isopropyl iodide → tert-Butyl (2S,4S)-4-{[(5-fluoro-1-isopropyl-1H-indazol-3-yl)carbonyl]amino}-2-(2-methoxy-2-oxoethyl)pyrrolidine-1-carboxylate

反応式

[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[C:5]2[C:11]([NH:13][C@@H:14]1[CH2:18][N:17]([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[C@H:16]([CH2:26][C:27]([O:29][CH3:30])=[O:28])[CH2:15]1)=[O:12].I[CH:32]([CH3:34])[CH3:33]>>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH:32]([CH3:34])[CH3:33])[N:6]=[C:5]2[C:11]([NH:13][C@@H:14]1[CH2:18][N:17]([C:19]([O:21][C:22]([CH3:23])([CH3:24])[CH3:25])=[O:20])[C@H:16]([CH2:26][C:27]([O:29][CH3:30])=[O:28])[CH2:15]1)=[O:12]

参加物

反応物 2

HCID 6362Isopropyl iodide

HCID 67270785tert-Butyl (2S,4S)-4-{[(5-fluoro-1H-indazol-3-yl)carbonyl]amino}-2-(2-methoxy-2-oxoethyl)pyrrolidine-1-carboxylate

生成物 1

HCID 67271330tert-Butyl (2S,4S)-4-{[(5-fluoro-1-isopropyl-1H-indazol-3-yl)carbonyl]amino}-2-(2-methoxy-2-oxoethyl)pyrrolidine-1-carboxylate

実験手順

The title compound was prepared according to the procedure described in step 1 of Example 4 from tert-butyl (2S,4S)-4-{[(5-fluoro-1H-indazol-3-yl)carbonyl]amino}-2-(2-methoxy-2-oxoethyl)pyrrolidine-1-carboxylate (step 1 of Example 25) and 2-iodopropane.

出典と根拠

ORDレコード: ord-de97a999d0ef4b68b911f6a5dad7f7d9
出典データセット: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07906532B2

反応ノート

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