関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-Methylbenzoxazole | HCID 7225 | — |
| 反応物 | N-bromobutanimide | HCID 67184 | — |
| 触媒 | Benzoyl Peroxide | HCID 7187 | — |
| 溶媒 | Carbon Tetrachloride | HCID 5943 | — |
| 生成物 | 2-(Bromomethyl)benzo[d]oxazole | HCID 12745944 | 17% |
反応手順
A solution of 35 g (0.263 mol) of 2-methyl-benzooxazole in CCl4 (300 mL) was treated with 47 g (0.263, 1 eq) of NBS and 1 g of benzoyl peroxide. The mixture was refluxed (100° C.) over night then cooled. Succinimide was filtered off and the mixture was evaporated to dryness. Column chromatography yielded 9.2 g (17%) of 2-bromomethyl-benzooxazole as a light yellow oil, MS: 210, 212 (MH+). (H. Uno, M. Kurokawa, Y. Masuda, Chem. Pharm. Bull., 1981, 29, 2359).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07906546B2 |
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| 出典データセット | uspto-grants-2011_03 |
|---|
| ORD ID | ord-9ecd94bb63d24f9eb45f6d9f4213f937 |
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| 出典メモ | uspto-grants-2011_03 |
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