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18-Crown-6 → 2-Benzenesulfonylmethyl-benzooxazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 18-Crown-6 | HCID 28557 | — |
| 反応物 | Benzenesulfinic acid, sodium salt | HCID 2723840 | — |
| 反応物 | 2-(Bromomethyl)benzo[d]oxazole | HCID 12745944 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 2-Benzenesulfonylmethyl-benzooxazole | HCID 12475398 | 70% |
反応手順
To 9.1 g (0.043 mol) of 2-bromomethyl-benzooxazole in CH3CN (300 mL) were added 7.39 g (0.045 mol, 1.05 eq) of benzenesulfinic acid sodium salt and 2.27 g (8.6 mmol, 0.2 eq) of 18-crown-6. Stirring was continued overnight, solvent evaporated and a column chromatography afforded 8.1 g (70%) of 2-benzenesulfonylmethyl-benzooxazole as a white solid, MS: 274 (H+). (Y. Nagao, S. Yamada, E. Fujita, Tet. Lett., 1983, 24, 2291)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07906546B2 |
| 出典データセット | uspto-grants-2011_03 |
| ORD ID | ord-c29c9a0c22224811a7955def82770b32 |
| 出典メモ | uspto-grants-2011_03 |