Sulfuric Acid → 4-(2,4,5-Trifluorophenyl)cyclohexanone

HRID 602938

反応式

HRID 602938 の反応式
[F:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([F:9])=[CH:4][C:3]=1[CH:10]1[CH2:19][CH2:18][C:13]2(OCC[O:14]2)[CH2:12][CH2:11]1.O1CCOCC1.S(=O)(=O)(O)O>O>[F:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([F:9])=[CH:4][C:3]=1[CH:10]1[CH2:11][CH2:12][C:13](=[O:14])[CH2:18][CH2:19]1

参加物

5

反応物 3

HCID 1118Sulfuric AcidHCID 312751,4-DioxaneHCID 574243618-(2,4,5-Trifluorophenyl)-1,4-dioxaspiro[4.5]decane

生成物 1

HCID 574243624-(2,4,5-Trifluorophenyl)cyclohexanone

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

8-(2,4,5-Trifluorophenyl)-1,4-dioxaspiro[4.5]decane (19 g) was added to a solution of 1,4-dioxane (600 mL), water (160 mL) and concentrated sulfuric acid (160 mL) and the resultant mixture was stirred for one h. The solution was then mixed with water (1 L) and extracted with dichloromethane (1 L). The organic layer was washed with water, dried over anhydrous magnesium sulfate filtered and evaporated to yield the title compound as a white solid.

後処理

  1. extractionextracted with dichloromethane (1 L)
  2. washThe organic layer was washed with water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. filtrationfiltered
  5. customevaporated

出典と根拠

ORDレコード
ord-3bf504553a684900b45daca18d902602
出典データセット
uspto-grants-2011_03
特許番号
US07906649B2

関連ノート

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