Cyanogen Bromide → 3-[(S)-(3-{(1S)-1-[3-(5-amino-1,3,4-oxadiazol-2-yl)-5-fluorophenyl]-2-fluoro-2-methylpropyl}azetidin-1-yl)(4-chlorophenyl)methyl]benzonitrile

反応式

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([C:29]2[CH:34]=[CH:33][CH:32]=[C:31]([C:35]#[N:36])[CH:30]=2)[N:9]2[CH2:12][CH:11]([C@@H:13]([C:18]3[CH:19]=[C:20]([CH:25]=[C:26]([F:28])[CH:27]=3)[C:21]([NH:23][NH2:24])=[O:22])[C:14]([F:17])([CH3:16])[CH3:15])[CH2:10]2)=[CH:4][CH:3]=1.C([O-])(O)=O.[Na+].[N:42]#[C:43]Br>O1CCOCC1.O>[NH2:42][C:43]1[O:22][C:21]([C:20]2[CH:19]=[C:18]([C@H:13]([CH:11]3[CH2:12][N:9]([C@@H:8]([C:5]4[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=4)[C:29]4[CH:30]=[C:31]([CH:32]=[CH:33][CH:34]=4)[C:35]#[N:36])[CH2:10]3)[C:14]([F:17])([CH3:16])[CH3:15])[CH:27]=[C:26]([F:28])[CH:25]=2)=[N:23][N:24]=1