Hydrochloric Acid → (r)-Piperidin-2-ylmethanol hydrochloride

HRID 60300ノート

反応式

HRID 60300 の反応式
[OH:1][CH2:2][C@H:3]1[CH2:8][CH2:7][CH2:6][CH2:5][N:4]1C(OC(C)(C)C)=O.[ClH:16]>O1CCOCC1>[ClH:16].[NH:4]1[CH2:5][CH2:6][CH2:7][CH2:8][C@@H:3]1[CH2:2][OH:1]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 6933953tert-butyl (2R)-2-(hydroxymethyl)piperidine-1-carboxylate

生成物 1

HCID 67247105(r)-Piperidin-2-ylmethanol hydrochloride収率 100.4%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

A mixture of (R)-tert-butyl 2-(hydroxymethyl)piperidine-1-carboxylate (840 mg, 3.9 mmol) in 1,4-dioxane (15 mL) was treated with hydrogen chloride (4.0N solution in dioxane, 9.8 mL, 39 mmol), and stirred at ambient temperature for 3 hours. The solvent was evaporated in vacuo to afford the title compound as a white solid (594 mg). 1H NMR (400 MHz, d6-DMSO) δ 8.75 (s, 1H), 4.72 (t, J=5.3, 1H), 3.35 (m, 1H), 3.28-3.15 (m, 3H), 2.72 (m, 1H), 2.59-2.52 (m, 1H), 1.88-1.72 (m, 2H), 1.72-1.53 (m, 2H), 1.16 (m, 1H).

後処理

  1. customThe solvent was evaporated in vacuo

出典と根拠

ORDレコード
ord-5c9bc136dd124595a5d6f84332c05f9b
出典データセット
uspto-grants-2016_09
特許番号
US09440976B2

反応ノート

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