Boron tribromide → 4-Bromocatechol

HRID 603092

反応式

HRID 603092 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([O:10]C)[C:5]([O:8]C)=[CH:6][CH:7]=1.B(Br)(Br)Br>ClCCl>[Br:1][C:2]1[CH:3]=[C:4]([OH:10])[C:5](=[CH:6][CH:7]=1)[OH:8]

参加物

4

反応物 2

HCID 25134Boron tribromideHCID 76114Benzene, 4-bromo-1,2-dimethoxy-

生成物 1

HCID 284874-Bromocatechol収率 96.1%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

6.51 g (0.0300 mol) of 4-bromoveratrole is dissolved in 50 ml of dichloromethane. To this suspension is added 37.6 g (0.150 mol) of boron tribromide at 0° C. The mixture was stirred for 3 hours at room temperature. Solvents were removed under reduced pressure. The resulting brown oil was dissolved in ethyl acetate and filtered through a pad of silica gel. The filtrate was concentrated to afford 5.45 g of 4-bromo catechol as a fight, brown oil.

後処理

  1. customSolvents were removed under reduced pressure
  2. dissolutionThe resulting brown oil was dissolved in ethyl acetate
  3. filtrationfiltered through a pad of silica gel
  4. concentrationThe filtrate was concentrated

出典と根拠

ORDレコード
ord-78a19679612140a9b7842b32d540d6c0
出典データセット
uspto-grants-2011_03
特許番号
US07906648B2

関連ノート

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