Hydrochloric Acid → N-(3,4-dichlorophenyl)piperidine-4-carboxamide hydrochloride

HRID 603239ノート

反応式

HRID 603239 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]([CH:12]2[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]2)=[O:11])[CH:5]=[CH:6][C:7]=1[Cl:8].Cl>ClCCl.O1CCOCC1>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]([CH:12]2[CH2:13][CH2:14][NH:15][CH2:16][CH2:17]2)=[O:11])[CH:5]=[CH:6][C:7]=1[Cl:8]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 9041882Tert-butyl 4-((3,4-dichlorophenyl)carbamoyl)piperidine-1-carboxylate

生成物 1

HCID 54595048N-(3,4-dichlorophenyl)piperidine-4-carboxamide hydrochloride収率 176.8%

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 312751,4-Dioxane溶媒

実験手順

To a solution of tert-butyl 4-{[(3,4-dichlorophenyl)amino]carbonyl}piperidine-1-carboxylate (3.0 g) in dichloromethane (15 mL) was added 4M HCl in dioxane (15 mL). The mixture was stirred at room temperature for 1 hour and then filtered to give the title compound as a white solid (2.2 g, 100%).

後処理

  1. filtrationfiltered

出典と根拠

ORDレコード
ord-8615b9f508144ffb93095bd1345c3394
出典データセット
uspto-grants-2011_03
特許番号
US07906645B2

反応ノート

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