2,3,6-Trifluorophenol → N-(2',3',6'-trifluorophenyl)-N-chloroacetyl-4-ethylaniline

HRID 603350ノート

反応式

HRID 603350 の反応式
[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[C:4]([F:9])[C:3]=1O.[Cl:11][CH2:12][C:13]([NH:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][CH3:23])=[CH:18][CH:17]=1)=[O:14]>>[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[C:4]([F:9])[C:3]=1[N:15]([C:13](=[O:14])[CH2:12][Cl:11])[C:16]1[CH:17]=[CH:18][C:19]([CH2:22][CH3:23])=[CH:20][CH:21]=1

参加物

3

反応物 2

HCID 5179882,3,6-TrifluorophenolHCID 7209622-chloro-N-(4-ethylphenyl)acetamide

生成物 1

HCID 66897441N-(2',3',6'-trifluorophenyl)-N-chloroacetyl-4-ethylaniline

実験手順

Same procedure as example 6a, starting from 2,3,6-trifluorophenol and 2-chloro-N-(4-ethylphenyl)acetamide. The crude intermediate N-(2′,3′,6′-trifluorophenyl)-4-ethylaniline was roughly purified by filtration on silica using toluene as eluent.

後処理

  1. filtrationThe crude intermediate N-(2′,3′,6′-trifluorophenyl)-4-ethylaniline was roughly purified by filtration on silica

出典と根拠

ORDレコード
ord-adc3893cfe5b46e49d1f920ea14d36df
出典データセット
uspto-grants-2011_03
特許番号
US07906677B2

反応ノート

読み込み中…