Chlorambucil → HCID 178426856、化合物

HRID 604405

反応式

HRID 604405 の反応式
[CH:1]1[C:6]([CH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11])=[CH:5][CH:4]=[C:3]([N:13]([CH2:17][CH2:18][Cl:19])[CH2:14][CH2:15][Cl:16])[CH:2]=1.[CH3:20][C:21]1([CH3:31])[N:26]([O:27])[C:25]([CH3:29])([CH3:28])[CH2:24][CH:23]([OH:30])[CH2:22]1>>[CH:5]1[C:6]([CH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11])=[CH:1][CH:2]=[C:3]([N:13]([CH2:14][CH2:15][Cl:16])[CH2:17][CH2:18][Cl:19])[CH:4]=1.[CH3:20][C:21]1([CH3:31])[N:26]([O:27])[C:25]([CH3:29])([CH3:28])[CH2:24][CH:23]([OH:30])[CH2:22]1

参加物

3

反応物 2

HCID 2708ChlorambucilHCID 137994Tempol

生成物 1

HCID 178426856HCID 178426856、化合物

実験手順

All the peaks for the product are visible with a slight trace of impurity; proton signal of the reduced nitroxyl radical appears as a broad hump between 8 to 10 ppm. The peaks belonging to the chlorambucil moiety of the adduct are well characterized with the para substituted aromatic protons appearing in the region between 6.5 to 7.03 ppm. The dimethyl groups of TEMPOL appear together as a singlet at 1.3 ppm and the methylene groups at 1.75 -2.07 ppm, the N, N-diethyl chloride peaks in the region between 3.5 and 3.7ppm and the peaks belonging to the butanoic acid chain in the region of 1.75-1.93 and 2.2 -2.5 ppm, as indicated in the following table.

出典と根拠

ORDレコード
ord-a71ebc9877ef4061a22f971a6868a9c0
出典データセット
uspto-grants-2011_03
特許番号
US07910607B2

関連ノート

読み込み中…