Iodine → N-(5-Furan-3-yl-4-phenyl-thiazol-2-yl)-formamide

HRID 604479ノート

反応式

HRID 604479 の反応式
[O:1]1[CH:5]=[CH:4][C:3]([CH2:6][C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=O)=[CH:2]1.[NH2:15][C:16]([NH2:18])=[S:17].II.[NH4+].[OH-].CN([CH:26]=[O:27])C>O>[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[S:17][C:16]([NH:18][CH:26]=[O:27])=[N:15][C:7]=2[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:2]1

参加物

7

反応物 5

HCID 807IodineHCID 6228DimethylformamideHCID 14923Ammonium HydroxideHCID 2723790ThioureaHCID 577096042-Furan-3-yl-1-phenyl-ethanone

生成物 1

HCID 57709597N-(5-Furan-3-yl-4-phenyl-thiazol-2-yl)-formamide

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
100 °C

実験手順

To a solution of 2-furan-3-yl-1-phenyl-ethanone (5.7 g, 31 mmol) and thiourea (4.7 g, 61 mmol) in DMF (57 mL) was and added iodine (7.8 g, 31 mmol). The reaction mixture was heated at 100° C. overnight, then it was diluted with water and made alkaline with saturated aqueous NH4OH, and extracted with ether. The organic phases were washed with water, dried over sodium sulfate, concentrated and purified on neutral Al2O3 using 50% ethyl acetate in hexane as eluent. Yield: 5.7 g, 69%.

後処理

  1. extractionextracted with ether
  2. washThe organic phases were washed with water
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated
  5. custompurified on neutral Al2O3 using 50% ethyl acetate in hexane as eluent

出典と根拠

ORDレコード
ord-d0bd42ae18bd45618907eeee605def21
出典データセット
uspto-grants-2011_03
特許番号
US07910613B2

反応ノート

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