Iodine → 2-Amino-4-Phenylthiazole-5-carbonitrile

HRID 604483ノート

反応式

HRID 604483 の反応式
Br[CH:2]([C:5](=O)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[C:3]#[N:4].[NH2:13][C:14]([NH2:16])=[S:15].II.[NH4+].[OH-]>O>[NH2:16][C:14]1[S:15][C:2]([C:3]#[N:4])=[C:5]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=2)[N:13]=1

参加物

6

反応物 4

HCID 807IodineHCID 14923Ammonium HydroxideHCID 2723790ThioureaHCID 119615962-Bromo-3-oxo-3-phenylpropanenitrile

生成物 1

HCID 214555522-Amino-4-Phenylthiazole-5-carbonitrile

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

2-Bromo-3-oxo-3-phenylpropionitrile (0.5 g, 3.4 mmol) was mixed with thiourea (0.52 g, 6.8 mmol) and iodine (0.43 g, 3.4 mmol) and the mixture was heated on a steam bath for 12 h. It was then diluted with water and made alkaline with saturated aqueous NH4OH, and extracted with ethyl acetate. The organic phases were washed with water and brine, dried over sodium sulfate, and evaporated to dryness to give the crude product, which was used in the next reaction without any further purification. Yield: 0.2 g, 29%.

後処理

  1. temperaturethe mixture was heated on a steam bath for 12 h
  2. extractionextracted with ethyl acetate
  3. washThe organic phases were washed with water and brine
  4. dry with materialdried over sodium sulfate
  5. customevaporated to dryness

出典と根拠

ORDレコード
ord-03d78c88d23b42f9abb204f8b42379f8
出典データセット
uspto-grants-2011_03
特許番号
US07910613B2

反応ノート

読み込み中…