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2-Nitrophenol → 2-nitrophenyl 2,3,4-tri-O-acetyl-5-thio-beta-D-xylopyranoside
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Nitrophenol | HCID 6947 | — |
| 反応物 | 2,3,4-tri-O-acetyl-5-thio-alpha-xylopyranosyl bromide | HCID 10926314 | — |
| 触媒 | Zincchloride | HCID 3007855 | — |
| 触媒 | Silver imidazolate | HCID 10931941 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-nitrophenyl 2,3,4-tri-O-acetyl-5-thio-beta-D-xylopyranoside | HCID 15067858 | 15.3% |
反応手順
If the procedure described in Preparation LXXXIII is followed starting from 2 g (14.4.10-3 mol) of 2-nitrophenol, 2.5 g (14.2.10-3 mol) of silver imidazolate, 6 g (15.7.10-3 mol) of 2,3,4-tri-O-acetyl-5-thio-α-D-xylopyranosyl bromide and 4 g (29.3.10-3 mol) of zinc chloride in 80 ml of methylene chloride, 0.91 g (yield: 15%) of the expected product is obtained after purification by chromatography on silica gel using a hexane/ethyl acetate mixture (2/1 v/v) as the eluent, and precipitation in ether.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05246961 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-06ef2526ca4b4e82962cc682dc5f8a8a |
| 出典メモ | uspto-grants-1993_09 |