2-Bromo-1-(5-bromo-2-methoxyphenyl)ethan-1-one → HCID 25107260、化合物

反応式

Br[CH2:2][C:3]([C:5]1[CH:10]=[C:9]([Br:11])[CH:8]=[CH:7][C:6]=1[O:12][CH3:13])=O.[N:14]1([C:19]2[CH:24]=[CH:23][C:22]([NH:25][C:26]([NH2:28])=[S:27])=[CH:21][C:20]=2[O:29][CH3:30])[CH:18]=[CH:17][N:16]=[CH:15]1>>[Br:11][C:9]1[CH:8]=[CH:7][C:6]([O:12][CH3:13])=[C:5]([C:3]2[N:28]=[C:26]([NH:25][C:22]3[CH:23]=[CH:24][C:19]([N:14]4[CH:18]=[CH:17][N:16]=[CH:15]4)=[C:20]([O:29][CH3:30])[CH:21]=3)[S:27][CH:2]=2)[CH:10]=1

参加物

反応物 2

HCID 27568502-Bromo-1-(5-bromo-2-methoxyphenyl)ethan-1-one

HCID 86624683HCID 86624683、化合物

生成物 1

HCID 25107260HCID 25107260、化合物

実験手順

The title compound was prepared in analogy to example 1 step e) from 232 mg (0.75 mmol) 2-bromo-1-(5-bromo-2-methoxyphenyl)ethanone and 170 mg (0.68 mmol) (4-imidazol-1-yl-3-methoxy-phenyl)-thiourea yielding 130 mg (41%) [4-(5-bromo-2-methoxy-phenyl)-thiazol-2-yl]-(4-imidazol-1-yl-3-methoxy-phenyl)-amine as a light yellow solid. MS ISP (m/e): 457.1/459.3 (100/90) (M+H)+.

出典と根拠

ORDレコード: ord-66318a1b94134fe082533eb8a29b2c17
出典データセット: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07910740B2

反応ノート

読み込み中…

参加物