2-Bromo-1,2-diphenylethan-1-one → (4,5-Diphenyl-thiazol-2-yl)-[4-(4-methyl-imidazol-1-yl)-phenyl]-amine

関与物質

反応手順

Prepared in analogy to example 64d) from 100 mg (0.43 mmol) [4-(4-methyl-imidazol-1-yl)-phenyl]-thiourea (example 72c)) and 130 mg (0.47 mmol) desyl bromide. 155 mg (88%) of the product was isolated as a colorless solid. MS ISP (m/e): 409.3 (100) (M+H)+. 1H NMR (DMSO-D6, 300 MHz): δ (ppm)=10.74 (s, 1H), 9.50 (s, 1H), 8.00-7.90 (m, 3H), 7.73 (d, 2H), 7.49 (d, 2H), 7.40-7.30 (m, 8H), 2.35 (s, 3H).

情報源と証拠