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(1-Chloropropyl)benzene → (2R)-2-({2-Amino-5-[(1-phenylpropyl)thio][1,3]thiazolo[4,5-d]pyrimidin-7-yl}amino)-4-methylpentan-1-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (1-Chloropropyl)benzene | HCID 524241 | — |
| 反応物 | HCID 178445911 | HCID 178445911 | — |
| 生成物 | (2R)-2-({2-Amino-5-[(1-phenylpropyl)thio][1,3]thiazolo[4,5-d]pyrimidin-7-yl}amino)-4-methylpentan-1-ol | HCID 11842649 | 31% |
反応手順
The title compound was synthesized as a mixture of two diastereomers by general method A from the reaction of (2R)-2-[(2-amino-5-mercapto[1,3]thiazolo[4,5-d]pyrimidin-7-yl)amino]-4-methylpentan-1-ol (30 mg, 100 μmol) with (1-chloropropyl)benzene (15.5 μL, 100 μmol) to give 13 mg (31% yield) as an oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09440992B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-a0d16a08c84946b5b53fcdbf122a77cd |
| 出典メモ | uspto-grants-2016_09 |