3-Bromo-N-[5-(4-hydroxy-phenylsulfanyl)-2-methyl-4-nitro-phenyl]-benzamide → N-[4-Amino-5-(4-hydroxy-phenylsulfanyl)-2-methyl-phenyl]-3-bromo-benzamide

HRID 605291ノート

反応式

HRID 605291 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:26]=[CH:27][CH:28]=1)[C:5]([NH:7][C:8]1[CH:13]=[C:12]([S:14][C:15]2[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=2)[C:11]([N+:22]([O-])=O)=[CH:10][C:9]=1[CH3:25])=[O:6].OC1C=CC(SC2C([N+]([O-])=O)=CC(C)=C(NC(=O)CC3C=CC=CC=3)C=2)=CC=1>>[NH2:22][C:11]1[C:12]([S:14][C:15]2[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=2)=[CH:13][C:8]([NH:7][C:5](=[O:6])[C:4]2[CH:26]=[CH:27][CH:28]=[C:2]([Br:1])[CH:3]=2)=[C:9]([CH3:25])[CH:10]=1

参加物

3

反応物 2

HCID 670402513-Bromo-N-[5-(4-hydroxy-phenylsulfanyl)-2-methyl-4-nitro-phenyl]-benzamide2 回HCID 67041085N-[5-(4-Hydroxy-phenylsulfanyl)-2-methyl-4-nitro-phenyl]-2-phenyl-acetamide

生成物 1

HCID 67040607N-[4-Amino-5-(4-hydroxy-phenylsulfanyl)-2-methyl-phenyl]-3-bromo-benzamide収率 86%

実験手順

The product from Example 266B was reacted according to the procedure from Example 265C substituting the product from Example 266B for the product from Example 265B to provide the title compound as a brown solid (0.164 g, 86%). This material was utilized without purification by silica gel chromatography.

出典と根拠

ORDレコード
ord-e534153dea784af89212a3a177600d82
出典データセット
uspto-grants-2011_03
特許番号
US07910595B2

反応ノート

読み込み中…